Asociaciones entre las concentraciones de cobre sérico, cobre hepático y ceruloplasmina sérica en equinos

• Autores: Pierre Boulou O, M. Noro, Helga Böhmwald L, F. Wittwer
• Localización: Revista MVZ Córdoba, ISSN 0122-0268, ISSN-e 1909-0544, Vol. 18, Nº. 3, 2013, págs. 3891-3896
• Idioma: español
• Títulos paralelos:
  • Associations between copper concentrations in liver and serum and ceruloplasmin in serum from horses
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• Resumen
  • español

    Objetivo. Determinar los valores y el grado de asociacion entre las concentraciones de cobre (Cu) hepatico y serico y de ceruloplasmina (Cp) serica en equinos. Materiales y metodos. Se utilizaron 38 equinos adultos, beneficiados en plantas faenadoras de la Region de la Araucania, Chile. Se obtuvieron muestras de sangre por venopuncion yugular previo al beneficio para determinar las concentraciones sericas de Cu y de Cp y, de higado posterior al beneficio para determinar la concentracion de Cu. Se calculo los intervalos de referencia y la asociacion entre las concentraciones de Cu hepatico y serico y Cp serica mediante correlacion de Pearson y regresion lineal. Resultados. Se estimaron intervalos para las concentraciones de Cu hepatico (32 - 161 �Êmol/kg de materia humeda) y serico (10 . 24 �Êmol/L) y, para Cp serica (0.08 - 0.43 �¢DO). Los valores de Cu hepatico, al ser comparados con los reportados por la literatura, indican que los animales presentaron un nivel adecuado de Cu, a excepcion de 1 caballo, que se encontro bajo el limite inferior. La cupremia se asocio con la concentracion serica de Cp (r=0.49; p<0.05), no apreciandose asociacion entre las otras variables (p>0.05). Conclusiones.

    Las concentraciones de Cu hepatico de equinos adultos, beneficiados en plantas faenadoras de la Region de la Araucania, Chile, se encontraron dentro de los intervalos descritos en la literatura. Las concentraciones de Cu hepatico no se asociaron con las de Cu o Cp sericas.

  • English

    Objective. The aim of this study is to determine the reference intervals and the associations between the concentrations of liver and blood serum copper (Cu) and serum ceruloplasmin (Cp) in horses.

    Materials and Methods. Thirty eight adults horses slaughtered in the Araucania Region, Chile, were used for this study. Blood samples were obtained by jugular venipuncture for determination of serum Cu and Cp concentrations and a sample of liver, 10 g, was obtained after the animal was slaughtered to determine Cu concentration. The reference intervals were calculated and the correlation between serum and liver Cu concentration and serum Cp were determined using Pearson correlation and lineal regression. Results. Reference interval values for liver Cu (32 -161 mmol/kg wet matter), serum Cu (10 - 24 mmol/L) and Cp (0.08 -0.43 ÄDO) concentrations were established. Horses had adequate Cu status according with the liver Cu values, when compared with literature, except one horse which was under the lower reference limit. Serum concentrations of Cu and Cp were associated (r=0.49, p<0.05);

    but no appreciable association between the other variables (p>0.05) was found. Conclusions. Liver Cu concentrations of adult horses slaughtered in the region of Araucania, Chile, are within the intervals described in the literature. Liver Cu concentration was not associated with serum concentration of Cu or ceruloplasmin, and a moderate association between these last two variables was found.