Alternative translation initiation in immunity: MAVS learns new tricks

• Autores: Pavel Ivanov, Paul Anderson
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 5, 2014, págs. 188-189
• Idioma: inglés
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• Resumen

  • Translational control of gene expression contributes to various aspects of immune function . Recent results by Brubaker et al. show how alternative translation initiation produces distinct isoforms of Mitochondrial Antiviral Signaling (MAVS), an adaptor protein associated with RIG-I and MDA5 that possess unique immunomodulatory properties.