Type 2 Diabetes Mellitus and Hypertension: An Update

• Autores: Guido Lastra, Sofia Syed, L. Romayne Kurukulasuriya, Camila Manrique, James R. Sowers
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 43, Nº. 1, 2014 (Ejemplar dedicado a: Diabetes Mellitus: Associated Conditions), págs. 103-122
• Idioma: inglés
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• Resumen

  • Patients with hypertension and type 2 diabetes are at increased risk of cardiovascular and chronic renal disease. Factors involved in the pathogenesis of both hypertension and type 2 diabetes include inappropriate activation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, impaired insulin-mediated vasodilatation, augmented sympathetic nervous system activation, altered innate and adaptive immunity, and abnormal sodium processing by the kidney. The renin-angiotensin-aldosterone system blockade is a key therapeutic strategy in the treatment of hypertension in type 2 diabetes. Emerging therapies for resistant hypertension as often exists in patients with diabetes, include renal denervation and carotid body denervation.