Visual Isotope Effects: Demonstrating the Primary Kinetic Isotope Effect in the Chromium(VI) Oxidation of 2-Propanol-d8 and Methanol-d4

• Autores: Wendy S. Iskenderian-Epps, Chloe Soltis, Daniel J. O�Leary
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 90, Nº 8, 2013, págs. 1044-1047
• Idioma: inglés
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• Resumen

  • The kinetic isotope e?ect in the Cr(VI) oxidation of commercially available 2-propanol-d8 or methanol-d4 is readily demonstrated using 4 mL reaction vials projected with a document camera. For the case of 2-propanol, the demonstration reveals how a rate-determining step can be identi?ed with an isotopically labeled compound, providing students with an example of how mechanistic evidence is experimentally determined. The 2-propanol oxidation demonstration has been documented in a YouTube video, which also discusses the relevant chemistry.