Manipulative activities have been used by many chemistry teachers to help students understand complex material and are often presented as games. The game described here is an in-classroom manipulative exercise that was devised to help prehealth and predietetics undergraduate majors understand the important concepts of the metabolic effects of the two antagonistic hormones insulin and glucagon in regulating human homeostasis. Student responses indicate that they believe the game increases their understanding of these effects and that they enjoyed playing the game. Pre and post activity assessments showed a significant difference in understanding the effects of the different hormones.
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