"IDEAL" Aging Is Associated with Lower Resting Metabolic Rate: The Baltimore Longitudinal Study of Aging

• Autores: Jennifer A. Schrack, Nicolas D. Knuth, Eleanor M. Simonsick, Luigi Ferrucci
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 62, Nº. 4, 2014, págs. 667-672
• Idioma: inglés
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• Resumen

  • Objectives: To assess the associations among age, health status, and resting metabolic rate (RMR) in a large population of older adults.

    Design: Cross-sectional analysis.

    Setting: Community-dwelling volunteers from the Baltimore Longitudinal Study of Aging (BLSA).

    Participants: Persons aged 40 to 96 (mean 68.2 ± 11.0) who underwent a comprehensive physical examination, cognitive assessment, RMR testing, body composition assessment, and physical function testing during a 3-day clinic visit (N = 420).

    Measurements: Participants were assigned to Insight into the Determination of Exceptional Aging and Longevity (IDEAL) or non-IDEAL categories based on health status. IDEAL participants were defined according to the absence of physical and cognitive impairments, chronic conditions and comorbidities, and blood profile abnormalities. A three-stage linear regression model was used to assess the relationship between RMR and age, using IDEAL classification as a predictor and adjusting for sex and body composition.

    Results: Resting metabolic rate averaged 1,512.4 ± 442.9 kcal/d and was lower with older age (? = -8.55, P < .001). After adjusting for age, sex, and body composition, RMR was 109.6 kcal/d lower in IDEAL than non-IDEAL participants (P < .005).

    Conclusion: Individuals who are fully functional and free of major medical conditions have lower RMR than those with disease and functional impairments. These findings suggest that health status plays a role in energy use and regulation independent of age and body composition and that elevated RMR may be a global biomarker of poor health in older persons.