Associations Between Serum 25-Hydroxyvitamin D Concentrations and Multiple Health Conditions, Physical Performance Measures, Disability, and All-Cause Mortality: The Concord Health and Ageing in Men Project

• Autores: Vasant Hirani, Robert G. Cumming, Vasikaran Naganathan, Fiona Blyth, David G. Le Couteur, David J. Handelsman, Louise M. Waite, Markus J. Seibel
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 62, Nº. 3, 2014, págs. 417-425
• Idioma: inglés
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• Resumen

  • Objectives: To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations.

    Design: Cross-sectional study, with additional prospective data on falls and mortality.

    Setting: Concord Health and Ageing in Men Project, Sydney, Australia.

    Participants: Community-dwelling men aged 70 and older (N = 1,659).

    Measurements: Serum 25(OH)D levels, general health status, self-reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls.

    Results: Fair, poor, and very poor health; self-reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all-cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater.

    Conclusion: Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men.