Eritema nudoso leproso y reacción de reversión en 2 casos de lepra importada

• Autores: A. Pulido Pérez, Dolores Mendoza Cembranos, José Antonio Avilés Izquierdo, Ricardo Suárez Fernández
• Localización: Actas Dermo-sifiliográficas, ISSN-e 1578-2190, ISSN 0001-7310, Vol. 104, fasc. 10, 2013, págs. 915-919
• Idioma: español
• Títulos paralelos:
  • Erythema Nodosum Leprosum and Reversal Reaction in 2 Cases of Imported Leprosy
• Texto completo no disponible (Saber más ...)
• Resumen
  • español

    Resumen Las leprorreacciones suponen cambios clínicos de inicio súbito en los pacientes que presentan formas inmunológicamente inestables de la enfermedad de Hansen. Estos cuadros pueden enmascarar los signos cardinales de la misma y demorar así su diagnóstico y tratamiento. Las principales complicaciones derivadas de este retraso son las relacionadas con la afectación neural, local (ulceraciones, piodermitis, osteomielitis, etc.) y/o sistémica característica de estos cuadros. Ante su sospecha debe realizarse un minucioso examen clínico, exploración de la sensibilidad y, cuando se precise, estudio histopatológico y microbiológico. La instauración inmediata de tratamiento antiinflamatorio disminuye el riesgo de secuelas funcionales, principal causa de morbilidad en la lepra. A continuación, se presentan 2 casos de leprorreacciones de tipo i y ii en pacientes no diagnosticados hasta ese momento de enfermedad de Hansen.

    -------------------------------------------------------------------------------- Abstract Leprosy reactions, which are abrupt changes in the clinical condition of patients with immunologically unstable forms of the disease, can mask the cardinal signs of leprosy, delaying both diagnosis and treatment. The main complications that arise from delayed diagnosis reflect the characteristic features of the disease, involving impaired nerve function and both local (ulcers, pyogenic infection, osteomyelitis) and systemic compromise. Through clinical examination, sensory testing, and, where necessary, histopathology and microbiology, are essential when leprosy is suspected. Rapid initiation of anti-inflammatory treatment reduces the risk of functional impairment, the main concern in leprosy. We describe type 1 and type 2 leprosy reactions in 2 patients who had not yet been diagnosed with the disease.

    Palabras clave Lepra; Enfermedad de Hansen; Vasculitis; Talidomida; Neuropatía Keywords Leprosy; Hansen disease; Vasculitis; Thalidomide; Neuropathy --------------------------------------------------------------------------------

  • English

    Abstract Leprosy reactions, which are abrupt changes in the clinical condition of patients with immunologically unstable forms of the disease, can mask the cardinal signs of leprosy, delaying both diagnosis and treatment. The main complications that arise from delayed diagnosis reflect the characteristic features of the disease, involving impaired nerve function and both local (ulcers, pyogenic infection, osteomyelitis) and systemic compromise. Through clinical examination, sensory testing, and, where necessary, histopathology and microbiology, are essential when leprosy is suspected. Rapid initiation of anti-inflammatory treatment reduces the risk of functional impairment, the main concern in leprosy. We describe type 1 and type 2 leprosy reactions in 2 patients who had not yet been diagnosed with the disease.