MyD88 and IL-1: Loosening T reg cells' firm grip

• Autores: Daniel J. Campbell
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 3, 2014, págs. 95-96
• Idioma: inglés
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• Resumen

  • Immune suppression by Treg cells must be overcome to mount robust and effective anti-pathogen immune responses. A new paper in Immunity from Medzhitov and colleagues shows that IL-1-dependent activation of MyD88 promotes the development of Th1 cells by rendering them impervious to Treg cell-mediated inhibition.