HCV-like IRESs sequester eIF3: advantage virus

• Autores: Debjit Khan, Prasanna Bhat, Saumitra Das
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 2, 2014, págs. 57-58
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • In a recent Nature paper, Hashem et al. attempted to probe deeper into the elusive role of eIF3 in translation initiation of viruses with hepatitis C virus-like internal ribosome entry sites (IRESs), but instead uncovered a surprising role of these IRESs in displacing eIF3 from the 40S subunit, favoring viral translation.