Bacterial toxins and small molecules elucidate endosomal trafficking

• Autores: Louise H. Slater, Anne E. Clatworthy, Deborah T. Hung
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 22, Nº. 2, 2014, págs. 53-55
• Idioma: inglés
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• Resumen

  • Bacterial toxins and small molecules are useful tools for studying eukaryotic cell biology. In a recent issue of PNAS, Gillespie and colleagues describe a novel small molecule inhibitor of bacterial toxins and virus trafficking through the endocytic pathway, 4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone (EGA), that prevents transport from early to late endosomes.