Impact of Restricted Maternal Weight Gain on Fetal Growth and Perinatal Morbidity in Obese Women With Type 2 Diabetes

• Autores: Björg Ásbjörnsdóttir, Signe S. Rasmussen, Louise Kelstrup, Peter Damm, Elisabeth Mathiesen
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 36, Nº. 5, 2013, págs. 1102-1106
• Idioma: inglés
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• Resumen

  • Abstract OBJECTIVE Since January 2008, obese women with type 2 diabetes were advised to gain 0�5 kg during pregnancy. The aim with this study was to evaluate fetal growth and perinatal morbidity in relation to gestational weight gain in these women.

    RESEARCH DESIGN AND METHODS A retrospective cohort comprised the records of 58 singleton pregnancies in obese women (BMI =30 kg/m2) with type 2 diabetes giving birth between 2008 and 2011. Birth weight was evaluated by SD z score to adjust for gestational age and sex.

    RESULTS Seventeen women (29%) gained =5 kg, and the remaining 41 gained >5 kg. The median (range) gestational weight gains were 3.7 kg (-4.7 to 5 kg) and 12.1 kg (5.5�25.5 kg), respectively. Prepregnancy BMI was 33.5 kg/m2 (30�53 kg/m2) vs. 36.8 kg/m2 (30�48 kg/m2), P = 0.037, and median HbA1c was 6.7% at first visit in both groups and decreased to 5.7 and 6.0%, P = 0.620, in late pregnancy, respectively. Gestational weight gain =5 kg was associated with lower birth weight z score (P = 0.008), lower rates of large-for-gestational-age (LGA) infants (12 vs. 39%, P = 0.041), delivery closer to term (268 vs. 262 days, P = 0.039), and less perinatal morbidity (35 vs. 71%, P = 0.024) compared with pregnancies with maternal weight gain >5 kg.

    CONCLUSIONS In this pilot study in obese women with type 2 diabetes, maternal gestational weight gain =5 kg was associated with a more proportionate birth weight and less perinatal morbidity.