Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility

• Autores: A. Cebrián, Miquel Tarón, N. Sala, Eva Ardanaz Aicua, María Dolores Chirlaque López, Nerea Larrañaga Larrañaga, M.-L. Redondo, Teresa Gómez del Pulgar, Carlos Camps Herrero, Rafael Rosell Costa, Carlos Alberto González Svatetz, Juan Carlos Lacal Sanjuán
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 16, Nº. 1, 2014, págs. 107-112
• Idioma: inglés
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• Resumen

  • Aim The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case�control association study if genetics variants in these pathways are associated with risk of developing lung cancer.

    Methods Thirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls.

    Results Six SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies.

    Conclusions Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer.