Taking the STING out of cytosolic DNA sensing

• Autores: Elie J. Diner, Russell E. Vance
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 1, 2014, págs. 1-2
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Detection of cytosolic DNA activates a downstream signaling molecule called STimulator of INterferon Genes (STING). Inappropriate or excessive activation of STING can lead to autoimmune disease. A new paper in Cell addresses the important question of how STING-dependent signaling is normally constrained.