Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats

• Autores: Kholoud S. Ramadan, Olfat A. Khalil, Enas N. Danial, Hanan S. Alnahdi, Najla O. Ayaz
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 69, Nº. 4, 2013, págs. 779-783
• Idioma: inglés
• Enlaces
  • Texto completo (pdf)
• Resumen

  • The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochemical parameters (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), accompanied by a significant decrease in the level of total protein and albumin in the STZ-induced rats when compared with that of the normal group. The high-dose treatment group (200 mg/kg body wt) significantly restored the elevated liver function enzymes near to normal. This study revealed that rosemary extracts exerted a hepatoprotective effect. The results indicate that the extract exhibits the protective effect on tissues and prove its potentials as an antidiabetic agent.