microRNAs in the kidney: novel biomarkers of Acute Kidney Injury
- Autores: Elia Aguado Fraile, Edurne Ramos, Elisa Conde, M. Rodríguez Fraile, Fernando Liaño García, Laura García Bermejo
- Localización: Nefrología: publicación oficial de la Sociedad Española de Nefrología, ISSN 0211-6995, Vol. 33, Nº. 6, 2013, págs. 826-834
- Idioma: inglés
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Resumen
microRNAs are small, endogenous RNA molecules which are critical for a new step in the regulation of the gene expression. They have become the most critical biological mediators characterized in the last ten years. microRNAs participate in almost every cellular process, therefore their deregulation is associated with the development of a wide range of pathologies, including kidney diseases. Increasing evidence demonstrates that microRNAs are key regulators of the normal kidney function and development, but they are also at the basis of several renal diseases. Recent works have established that these molecules can be secreted to extracellular environments, enabling their detection in pe - ripheral body fluids such as urine and serum. Moreover, circulating miRNAs detected in body fluids turn into suit - able biomarkers of kidney diseases, including acute kidney injury. This new generation of renal biomarkers could have a great impact in the clinical practice, significantly contrib - uting to improve patient management. In this review, we discuss over the implication of microRNAs in normal kidney function and homeostasis as well as the role of circulating miRNAs as novel biomarkers of kidney diseases, focusing on their potential usefulness in acute kidney injury man - agement.
