Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet

• Autores: Yildiz Öner-I.yidog(an, Hikmet Koçak, Muhammed Seyidhanoglu, Figen Gürdöl, Ahmet Gülçubuk, Funda Yildirim, Aydin Çevik, Müjdat Uysal
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 69, Nº. 4, 2013, págs. 677-686
• Idioma: inglés
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• Resumen

  • Fetuin-A is synthesized in the liver and is secreted into the bloodstream. Clinical studies suggest involvement of fetuin-A in metabolic disorders such as visceral obesity, insulin resistance, diabetes, and fatty liver. Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties. In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant�antioxidant status in rats fed a high-fat diet (HFD). Male Sprague�Dawley rats were divided into six groups. Group 1 was fed control diet (10 % of total calories from fat). Groups 2 and 3 were given curcumin (100 and 400 mg/kg bw/day, respectively ) by gavage for 8 weeks and were fed control diet. Group 4 was fed with HFD (60 % of total calories from fat). Groups 5 and 6 received HFD together with the two doses of curcumin, respectively. Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity.