Arterial Stiffness Is Inversely Related to Plasma Adiponectin Levels in Young Normotensive Patients With Type 1 Diabetes

• Autores: Afroditi Tsiakou, Stavros Liatis, Kleopatra Alexiadou, Evanthia Diakoumopoulou, Konstantinos Makrilakis, Nicholas Tentolouris, Despoina Kyriaki, Nicholas Katsilambros
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 36, Nº. 3, 2013, págs. 734-736
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Abstract OBJECTIVE This study investigated the association between arterial stiffness and plasma adiponectin in patients with type 1 diabetes.

    RESEARCH DESIGN AND METHODS Participants were normotensive patients with type 1 diabetes who were up to age 40 years. Subjects on statins with macrovascular disease or overt nephropathy were excluded. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV), whereas plasma adiponectin was measured by radioimmunoassay.

    RESULTS Data from 80 patients (age 27.1 ± 6.1 years, BMI 24.2 ± 3.1 kg/m2, HbA1c 7.5 ± 1.6%, 39 men, adiponectin 13.9 ± 6.7 µg/mL, and PWV 5.6 ± 0.9 m/s) were analyzed. Log adiponectin inversely correlated with age-adjusted PWV (r = -0.291, P = 0.009) and waist circumference (r = -0.427, P < 0.001). In a fully adjusted model, age, expiration/inspiration index, and log adiponectin were independently associated with PWV, explaining 39.6% of its variance.

    CONCLUSIONS Arterial stiffness is inversely related to adiponectin concentration in young patients with type 1 diabetes without major complications.