Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

• Autores: Nikolaos Daskalakis, Amy Lehrner, Rachel Yehuda
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 42, Nº. 3, 2013 (Ejemplar dedicado a: Endocrine and Neuropsychiatric Disorders), págs. 503-513
• Idioma: inglés
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• Resumen

  • Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder with multiple medical comorbidities. This article reviews the current literature on the endocrine aspects of PTSD, specifically hypothalamic-pituitary-adrenal axis alterations indicative of low cortisol and increased glucocorticoid sensitivity, and the proposed mechanisms whereby these alterations increase risk or reflect pathophysiology. Discussion includes novel treatment innovations and directions for future research.