A balance of interleukin-12 and -23 in cancer

• Autores: Shin Foong Ngiow, Michele W. L. Teng, Mark J. Smyth
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 34, Nº. 11, 2013, págs. 548-555
• Idioma: inglés
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• Resumen

  • Interleukin (IL)-12 and IL-23 share the IL-12p40 molecule. IL-12 promotes T helper (Th)1 immunity and IL-23 promotes Th17 immunity, and it has recently become apparent that the balance between IL-12 and IL-23 is important in carcinogenesis. A series of studies demonstrated that, where tumor initiation, growth, and metastasis are concerned, IL-12 may act independently of interferon (IFN)-?, and IL-23 independently of IL-17A. This review explores the activity of IL-23 in carcinogenesis. In the context of the tumor-inhibitory effects of IL-12, and tumor-promoting effects of IL-23, we discuss the use of anti-IL-12p/23 monoclonal antibodies (mAbs) in autoimmune inflammatory disorders and the alternative specific neutralization of IL-23.