Cholesterol: fa(s)t-food for enterovirus genome replication

• Autores: Jeroen R. P. Strating, Hilde M. van der Schaar, Frank J.M. van Kuppeveld
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 21, Nº. 11, 2013, págs. 560-561
• Idioma: inglés
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• Resumen

  • Hijacking and remodeling of host membranes is an obligatory step in the replicative cycle of (+)RNA viruses, including enteroviruses. Ilnytska et al. unveiled in Cell Host & Microbe that enteroviruses usurp clathrin-mediated endocytosis to shuttle cholesterol to sites of genome replication and that cholesterol is needed for efficient replication.