ß-Cell Mass and Turnover in Humans: Effects of obesity and aging

• Autores: Yoshifumi Saisho, Alexandra E. Butler, Erica Manesso, David Elashoff, Robert A. Rizza, Peter C. Butler
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 36, Nº. 1, 2013, págs. 111-117
• Idioma: inglés
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• Resumen

  • Abstract OBJECTIVE We sought to establish ß-cell mass, ß-cell apoptosis, and ß-cell replication in humans in response to obesity and advanced age.

    RESEARCH DESIGN AND METHODS We examined human autopsy pancreas from 167 nondiabetic individuals 20�102 years of age. The effect of obesity on ß-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects.

    RESULTS ß-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but ß-cell mass is remarkably preserved. There is minimal ß-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age.

    CONCLUSIONS ß-Cell mass in human obesity increases by ~50% by an increase in ß-cell number, the source of which is unknown. ß-Cell mass is well preserved in humans with advanced aging.