Immunohistochemical expression of Skp2 protein in oral nevi and melanoma

• Autores: Bruno Augusto Benevenuto de Andrade, Jorge Esquiche León, Román Carlos, Wilson A. Delgado Azañero, Adalberto Mosqueda Taylor, Oslei Paes de Almeida
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 18, Nº. 3, 2013, págs. 388-391
• Idioma: inglés
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• Resumen

  • Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas.

    Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melano - cytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was as - sessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide.

    Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein.

    Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral be - nign and malignant melanocytic lesions.