Expression and prognostic role of c-Myb as a novel cell cycle protein in esophageal squamous cell carcinoma

• Autores: H. Lu, Y. Wang, Y. Huang, H. Shi, Q. Xue, S. Yang, S. He, H. Wang
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 15, Nº. 10, 2013, págs. 796-801
• Idioma: inglés
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• Resumen

  • Purpose The c-Myb transcription factor controls differentiation and proliferation in hematopoietic and other cell types, and has latent in regulation during the cell cycle. Recent studies suggested that deregulation of c-Myb expression plays a key role in oncogenesis. To investigate the potential roles of c-Myb in esophageal carcinoma, expression of c-Myb was examined in human esophageal carcinoma samples.

    Methods Immunohistochemistry and Western blot analysis were performed for c-Myb in 87 esophageal carcinoma samples. The data were correlated with clinicopathological features. The univariate and multivariate survival analyses were also performed to determine their prognostic significance.

    Results c-Myb was overexpressed in esophageal carcinoma as compared with the adjacent normal tissue. High expression of c-Myb was associated with histological grade and was positively correlated with proliferation marker Ki-67 (P = 0.001). Univariate analysis showed that c-Myb expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that c-Myb was an independent prognostic marker for esophageal carcinoma (P < 0.001). While in vitro, following release from serum starvation of TE-1 esophageal carcinoma cell, the expression of c-Myb was upregulated.

    Conclusions Our results suggested that c-Myb overexpression is involved in the pathogenesis of esophageal carcinoma; it may be a favorable independent poor prognostic parameter for esophageal carcinoma.