Regulation of nuclear factor-kB in autoimmunity

• Autores: Shao Cong Sun, Jae-Hoon Chang, Jin Jin
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 34, Nº. 6, 2013, págs. 282-289
• Idioma: inglés
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• Resumen

  • Nuclear factor (NF)-?B transcription factors are pivotal regulators of innate and adaptive immune responses, and perturbations of NF-?B signaling contribute to the pathogenesis of immunological disorders. NF-?B is a well-known proinflammatory mediator, and its deregulated activation is associated with the chronic inflammation of autoimmune diseases. Paradoxically, NF-?B plays a crucial role in the establishment of immune tolerance, including both central tolerance and the peripheral function of regulatory T (Treg) cells. Thus, defective or deregulated activation of NF-?B may contribute to autoimmunity and inflammation, highlighting the importance of tightly controlled NF-?B signaling. This review focuses on recent progress regarding NF-?B regulation and its association with autoimmunity.