Sarcoidosis and Psoriasis: A Case Series and Review of the Literature Exploring Co-Incidence vs Coincidence

• Autores: Karolyn A. Wanat, Andras Schaffer, Veronica Richardson, Abby VanVoorhees, Misha Rosenbach
• Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 149, Nº. 7, 2013, págs. 848-852
• Idioma: inglés
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• Resumen

  • Importance Sarcoidosis is a chronic multisystem disorder characterized by the formation of noncaseating epithelioid cell granulomas affecting multiple organ systems. The role of the type 1 helper T (TH1) cell in sarcoidal granuloma formation has been well documented, and the TH17 pathway in sarcoidosis is just now being investigated. TH17 cells are also known to involved in the pathogenesis of psoriasis, and the coexistence of sarcoidosis and psoriasis is mechanistically plausible based on potential shared underlying immunologic pathways.