Effect of Radiation Therapy on Survival in Patients With Resected Merkel Cell Carcinoma: A Propensity Score Surveillance, Epidemiology, and End Results Database Analysis
- Autores: Julian A. Kim, Audrey H. Choi
- Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 149, Nº. 7, 2013, págs. 831-838
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Importance Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine malignant neoplasm that can be highly aggressive and ultimately lethal. However, the cumulatively low incidence rate has made it difficult to accrue patients to prospective randomized trials.
Objective To determine whether patients with MCC in the Surveillance, Epidemiology, and End Results (SEER) database who received radiation therapy after resection demonstrate improved survival.
Design The study population consisted of SEER patients with histologically confirmed MCC who underwent surgical resection between January 1, 1998, and December 30, 2006. Cox proprotional hazards regression models were used to determine factors associated with MCC-specific and overall survival. Propensity scoring with matched pairs was used to perform Kaplan-Meier survival analysis comparing patients who underwent surgery plus radiation therapy vs those who underwent surgery alone.
