Clinical Trials in Predementia Stages of Alzheimer Disease

• Autores: Jagan A. Pillai, Jeffrey L. Cummings
• Localización: Medical clinics of North America, ISSN 0025-7125, Vol. 97, Nº. 3, 2013 (Ejemplar dedicado a: Early Diagnosis and Intervention in Predementia Alzheimer's Disease), págs. 439-457
• Idioma: inglés
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• Resumen

  • Effective treatments of Alzheimer disease (AD) dementia are an urgent necessity. There is a growing consensus that effective disease-modifying treatment before the onset of clinical dementia and slowing the progression of mild symptoms are needed after recent setbacks in AD therapeutics. The identification of at-risk and preclinical AD populations is becoming important for targeting primary and secondary prevention clinical trials in AD. This article reviews the strategies and challenges in targeting at-risk and preclinical AD populations for a new generation of AD clinical trials. Design, outcome measures, and complexities in successfully completing a clinical trial targeting this population are reviewed.