Psoriasis as Autoinflammatory Disease

• Autores: Joaquin J. Rivas Bejarano, Wendell C. Valdecantos
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 31, Nº. 3, 2013 (Ejemplar dedicado a: Autoinflammatory Disorders), págs. 445-460
• Idioma: inglés
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• Resumen

  • This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined features, and an associated or concomitant systemic inflammatory state that involves a multifactorial cellular and molecular network, transforming the old perception of psoriasis as a localized autoimmune skin disease, to one of psoriasis as a systemic inflammatory disease with autoinflammatory features and severe associated comorbid conditions.