Effects of the relationship between 65Zn and blood cells. A dynamic and morphological study

• Autores: Arturo Vera Gil, María Jesús Pérez Castejón, Jaime Whyte Orozco, Ana Isabel Cisneros Gimeno, Paula Barba Recreo, M. Lahoz, C. Pérez-Castejón
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 28, Nº. 8, 2013, págs. 1007-1011
• Idioma: inglés
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• Resumen

  • We have studied the dynamic pathway of 65Zn and its autoradiographic location in blood cells, even at the ultra-structural level. We have found evidence that tends to confirm the old biochemical postulates about the capacity of this isotope to displace iron in the haemoglobin molecule.

    Recently, the bibliography has demonstrated that 57Co is also able to perform this displacement, but unlike 65Zn it does not invalidate the Redox function of the molecule.

    In the case of 65Zn, the mentioned displacement invalidates this function because the radionuclide can only use valence 2. We have also contributed evidence of erythrocytes destruction by the spleen after the incorporation of 65Zn, as well as the clearly marked degradation of haematic pigments inside the spleen.