Farmacogenómica: ¿Equilibrio entre ciencia y ética?

• Autores: L. Tracey, I. Spiteri, Miguel Ángel Piris Pinilla
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 4, Nº. 6, 2002, págs. 425-434
• Idioma: español
• Títulos paralelos:
  • Pharmacogenomics: A balance between science and ethics
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• Resumen

  • Pharmacogenomics studies the interaction between individual genetic factors and drugs' cytotoxicity, through the analysis of genetic bases of absorption, distribution, metabolism, elimination and affinity by the drugs' target receptor. Massive molecular techniques employed include techniques directed either towards testing the genetic variability of individuals (polymorphisms detected with SNPs) or towards identifying characteristic expression profiles by means of genomic or proteomic techniques. Pharmacogenomics' practical applications make reference to pharmacokinetics - the analysis of the alteration in drugs' concentration, absorption, activation or metabolism -; pharmacodynamics - the analysis of the interaction between the drug and its target -, as well as the analysis of the risk of disease associated with polymorphisms in genes involved in drugs' metabolism and/or the action mechanisms of such. The most important obstacle for a massive clinical application of pharmacogenomics resides on the ethical aspects, specially the protection of every patient's rights, and the access to the generated information