Hiperekplexia neonatal: Tratamiento con una formulatión oral de clonazepam

• Autores: Javier Sánchez-Rubio Ferrández, M.C. Girón Duch, F.J. Farfán Sedano, Nuria Ibáñez Heras, Ana Ontañón Nasarre
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 5, Nº. 5, 2003, págs. 310-312
• Idioma: español
• Títulos paralelos:
  • eng
  • Neonatal hyperekplexia: Treatment with an oral clonazepam formulation
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• Resumen

  • Objective: To describe a case of neonatal hyperekplexia as well as the preparation of an oral clonazepam solution for its treatment by the pharmacy department. Methods: Starting from a commercial 2.5 mg/ml clonazepam solution, a 0.01 mg/ml clonazepam solution is prepared by means of serial dilutions. Such solution is dispensed to the patient at the hospital as well as outside in an external patient regime. A follow-up of the patient's evolution during the treatment takes place. Results: The initial dosage of 0.025 mg/kg/day produced not only a quick improvement on the patient, but also excessive somnolence. By adjusting the dosage to 0.01 mg/kg/day, it was observed an excellent tolerance and clinical evolution, reaching the point of medication removal six months from the beginning of the treatment. Conclusions: The solution proved to be effective for the treatment of this disease, although it is necessary a posologic adjustment based on the response and the tolerance