Diabetes: Have We Got It All Wrong?: Insulin hypersecretion and food additives: cause of obesity and diabetes?

• Autores: Barbara E. Corkey
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 12, 2012, págs. 2432-2437
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Excess circulating lipids and amino acids can increase insulin secretion in the presence of normal circulating glucose levels. [...]in the setting of normal blood glucose, insulin elevation caused by fat or amino acids would result in hypoglycemia. Alternative considerations Environmental agents Almost nothing has remained constant during the several decades of the evolution of the diabetes epidemic: environmental temperature, altered chemicals in agricultural practice, the use of drugs in our food animals, and the processing and packaging of our foods (10). Diabetogenic agents Some environmental pollutants have been shown to alter B-cell function, although it has not yet been determined whether prevailing environmental concentrations of these types of compounds can be a risk factor for diabetes.\n Islets from lean littermates and obese Zucker and Zucker diabetic fatty rats were incubated for 24-h in vitro and exposed to 1 1 mmol/L glucose and 0.3 mmol/L palmitate (high fat, high carb) with or without rimonabant.