Resumen de Hábitos de vida, factores ambientales y fármacos asociados a infertilidad]
Objective: The objective of this study is to review the available bibliography about environmental factors, life habits and drugs that could produce the existence of infertility. Method: We conducted a systematic bibliographic search of the main databases. We also included those articles published in the last ten years. Results: Regarding the life habits, we highlight the influence of diet, exercise and toxic habits. Most of the existing bibliography about drugs that might negatively affect fertility makes reference to the oncologic treatment. Alquilant agents are the chemotherapeutic agents that most intensely produce azoospermia and ovarian failure. Regarding immunosuppressants, the most studied drugs are sirolimus, everolimus and tacrolimus. Hyperprolactinemia is an undesired side effect of using neuroleptics, both typical and atypical. Other relevant drugs are antiepileptics, antidepressants (mainly selective serotonin reuptake inhibitors), hormones and anti-inflammatory drugs (like sulfasalazine used in rheumatoid arthritis). Conclusions: There are numerous factors related to sterility. However, we do not exactly know the frequency in which these factors intervene. Most of the time, the medical practice focuses on the treatment of infertility, being also of great importance the educational work in the areas of health education and social consciousness-raising about its prevention. Regarding the drugs associated with sterility, we should substitute them for other ones in cases of couples that already have fertility problems or in cases of patients infertile age with the desire to procreate. This study is a review of drugs' association with fertility, and not of their teratogenic potential
