Resumen de Protocolo de dosificación y monitorización de aminoglucósidos y vancomicina en pacientes adultos
Nuria Bujaldón Querejeta, Mercedes González-Delgado, S.I. Ruiz Darbonnéns, M. Martínez Ramírez, Amparo Taléns Bolós
Objective: To elaborate and establish a protocol for dosing and monitoring aminoglycosides and vancomycin in adult hospitalized patients. Method: We reviewed a selection of articles and consensus guides of various scientific societies and groups of experts published in the last ten years, and elaborated a consensus protocol approved by the Infections Commission. Results: Protocol for dosing and monitoring of: 1) Aminoglycosides: The administration of aminoglycosides in a unique daily dose and the monitoring of trough concentrations seem to decrease the toxicity risk, while peak concentrations above the Minimal Inhibition Concentration (MIC) of the causing bacteria (Cmax/MIC > 10), are related to a probable increase in therapeutic efficacy based on pharmacokinetic and pharmacodynamic (PKJPD) parameters. 2) Vancomycin: Vancomycin's dosage pattern adjusted for trough concentrations has the purpose of achieving the index PK/PD value that better correlates with therapeutic efficacy, in the area under the 24-h curve (AUC24h)/MIC higher than 400. Conclusions: The implementation and development of a dosing and monitoring protocol for aminoglycosides and vancomycin in adult hospitalized patients could improve treatment optimization for these antibiotics
