Objective: To develop a risk index for identifying patients with risk of chronic medication-related problems (MRPc) after hospital admission. Method: Observational descriptive study. We included patients admitted to the hospital with chronic treatments. Main variable: presence of MPRc with initial severity = 2. We conducted a multivariate analysis to identify any risk factors. A risk index was developed based on the B coefficient of each independent variable by studying its diagnostic capacity. Results: 100 patients were included. The patient's urgent admission (B = 1), more than five chronic medications (B = 2) and high-risk chronic medications (B = 1) were related to a risk of MRPc. We created a risk index with values from 0 to 4 (maximum = 4). AUC ROC: 81.3% (CI 95%: 71.6 to 91.1%), sensitivity: 73.97%; specificity: 77.78% (cutoff point: 2). Conclusions: The obtained risk index allows for early identification of patients with MRPc risk at hospital admission
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