Pancreatic Steatosis and Its Relationship to [Beta]-Cell Dysfunction in Humans: Racial and ethnic variations

• Autores: Lidia S. Szczepaniak, Ronald G. Victor, Ruchi Mathur, Michael d. Nelson, Edward W. Szczepaniak, Nicole Iyer, Ida Chen, Roger H. Unger, Richard N. Bergman, Ildiko Lingvay
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 11, 2012, págs. 2377-2383
• Idioma: inglés
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• Resumen

  • To evaluate racial/ethnic differences in pancreatic triglyceride (TG) levels and their relationship to ?-cell dysfunction in humans. We studied black, Hispanic, and white adults who completed three research visits: screening and an oral glucose tolerance test; frequently sampled intravenous glucose tolerance tests for evaluation of ?-cell function and insulin resistance; and proton magnetic resonance spectroscopy for evaluation of pancreatic and hepatic TG levels. Pancreatic TG levels were higher in Hispanics and whites than in blacks (P = 0.006). Hepatic TG levels were highest in Hispanics (P = 0.004). Compensatory insulin secretion and disposition index were higher in blacks (P = 0.003 and ? = 0.024, respectively). Insulin sensitivity was comparable between Hispanics and blacks and was lower than in whites (P = 0.005). In blacks, compensatory insulin secretion increased steeply with small increments in pancreatic TG levels (R^sup 2^ = 0.45, slope = 247). In whites, the range of pancreatic TG levels was higher, and the slope was less steep than in blacks (R^sup 2^ = 0.27, slope = 27). In Hispanics, pancreatic TG levels were similar to those of whites, but compensatory insulin secretion was described by a combination of pancreatic and hepatic TG levels and visceral fat mass (R^sup 2^ = 0.32). In a multiethnic sample of adults with mild obesity and without diabetes, we found striking ethnic differences in the levels of pancreatic TGs and in the relationship between pancreatic TGs and ?-cell dysfunction. Our data implicate pancreatic TG content measured by proton magnetic resonance spectroscopy as a noninvasive novel biomarker for pancreatic ?-cell dysfunction, especially in the Hispanic population. [PUBLICATION ABSTRACT]