Resumen de Closed-Loop Systems: Diversity and Natural Selection
(1) report on the results of their iteration of a closed-loop system, their so-called bihormonal bionic endocrine pancreas, which incorporates one sensor component (Freestyle Navigator; Abbott Diabetes Care, Alameda, CA) and two distinct efferent hormonal outputs, insulin and glucagon, delivered two separate pumps (OmniPod; Insulet Corp., Bedford, MA), each under individalgorithmic control: an MPC-based for insulin and a proportionalderivative-based controller for glucagon.
