PAI-1 and Diabetes: A Journey From the Bench to the Bedside

• Autores: David J. Schneider, Burton E. Sobel
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 10, 2012, págs. 1961-1967
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • When it is elaborated into the blood it converts circulating plasminogen (present in high concentrations but biologically inert) to plasmin, a relatively nonspecific protease. Because both plasminogen and t-PA bind specifically to fibrin associated with nascent thrombi, the action of t-PA in blood is largely confined to clots, giving rise to what has been called clot-specific fibrinolysis (6). [...]coronary atherosclerotic plaques that form under such circumstances are likely to be relatively devoid of VSM, lipid laden, and prone to rupture, thereby precipitating acute coronary syndromes.