Postchallenge Hyperglycemia Is Positively Associatea With Diabetic Polyneuropathy:: The KORA F4 study

• Autores: Brenda W.C. Bongaerts, Wolfgang Rathmann, Bernd Kowall, Christian Herder, Doris Stôckl, Christa Meisinger, Dan Ziegler
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 9, 2012, págs. 1891-1893
• Idioma: inglés
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• Resumen

  • To assess the prevalence of distal sensorimotor polyneuropathy (DSPN) in an older population and to examine its relationship with prediabetes. Glucose tolerance status was determined in 61- to 82-year-old participants (n = 1,100) of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 Survey (2006-2008). Clinical DSPN was defined as bilaterally impaired foot-vibration perception and/or foot-pressure sensation. Prevalence of clinical DSPN was similar in subjects with known diabetes (22.0%) and subjects with combined impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) (23.9%). Among prediabetic subgroups, IFG-IGT, but not isolated-IFG and -IGT, was associated with a higher risk of clinical DSPN, compared with normal glucose tolerance. A J-shaped association was observed between clinical DSPN and quartiles of 2-h postchallenge glucose, but not with fasting glucose and HbA^sub 1c^ levels. Subjects with IFG-IGT and known diabetes had a similar prevalence of clinical DSPN. Elevated 2-h postload glucose levels appeared important for disease risk.