Severe Hypoglycemia Predicts Mortality in Diabetes

• Autores: Philip E. Cryer
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 9, 2012, págs. 1814-1816
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • [...]there was no evidence that the former group had more serious underlying disease, although their self-report of severe hypoglycemia predicted higher mortality 5 years later even after adjustment for age, sex, diabetes type and duration, hemoglobin Alc, and Charlson comorbidity index. The latter increases the risk of a fatal ventricular arrhythmia. [...]the mechanism of hypoglycemic death may involve an episode of recent antecedent iatrogenic hypoglycemia that 1) reduces baroreflex sensitivity, thereby setting the stage for a ventricular arrhythmia and 2) increases the likelihood of another episode of hypoglycemia with a sympathoadrenal discharge that triggers a ventricular arrhythmia (3).