Identification of Genetic Loci Associated With Helicobacter pylori Serologic Status

• Autores: Julia Mayerle, Caroline M. den Hoed, Claudia Schurmann
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 309, Nº. 18, 2013, págs. 1912-1920
• Idioma: inglés
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• Resumen

  • Importance Helicobacter pylori is a major cause of gastritis and gastroduodenal ulcer disease and can cause cancer. H pylori prevalence is as high as 90% in some developing countries but 10% of a given population is never colonized, regardless of exposure. Genetic factors are hypothesized to confer H pylori susceptibility.

    Objective To identify genetic loci associated with H pylori seroprevalence in 2 independent population-based cohorts and to determine their putative pathophysiological role by whole-blood RNA gene expression profiling.