Expression analysis of tumor-related genes involved in critical regulatory pathways in schwannomas

• Autores: M. Torres Martín, Victor Martinez-Glez, Carolina Peña Granero, Luis Lassaletta Atienza, Alberto Isla Guerrero, J. M. de Campos, Giovanny R. Pinto, Rommel R. Burbano, Bárbara Meléndez, Javier Sáez Castresana, Juan Antonio Rey Herranz
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 15, Nº. 5, 2013, págs. 409-411
• Idioma: inglés
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• Resumen

  • Purpose Gene expression array analysis is providing key data on the potential candidate genes and biological pathways involved in schwannoma origin and development. In this way we performed expression array studies on tumor-related genes in schwannomas.

    Methods The GE Array Q Series HS-006 (SuperArray, Bethesda, MD, USA) was used to determine the expression levels of 96 genes corresponding to 6 primary biological regulatory pathways in a series of 23 schwannomas.

    Results We identified 15 genes down-regulated, primarily corresponding to signal transduction functions, and 26 genes up-regulated, most frequently involving cell adhesion functions.

    Conclusions In addition to the NF2 inactivation (considered as an early step), variations of other biological regulatory pathways might play a key role in schwannoma.