Central Leucine Sensing in the Control of Energy Homeostasis

• Autores: Gary J. Schwartz
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 42, Nº. 1, 2013 (Ejemplar dedicado a: Neuroendocrine Control of Metabolism), págs. 81-87
• Idioma: inglés
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• Resumen

  • This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity