The purpose of the investigation was to observe the pineal�adrenal�immune system relationships and their influence on non-specific immune response in female goats under short-term thermal stress. Six female goats had been exposed to 40°C and 60% relative humidity in the psychrometric chamber for 17 days. Blood samples were obtained on days 0 and 10 to establish control and thermal stress effects, respectively. Chemical adrenalectomy was achieved by injecting metyrapone (100 mg/kg body weight) followed by exogenous melatonin treatment (0.1 mg/kg body weight) from 11th to 17th day of experiment. Thermal stress significantly (P ? 0.05) altered the physiological responses. Metyrapone and melatonin treatment significantly (P ? 0.05) reduced the thermal-stress-induced increase in plasma concentrations of cortisol and corticosterone while significantly (P ? 0.05) increased the plasma melatonin on days 11 and 17. Furthermore, these treatments significantly (P < 0.05) increased the phagocytic activity of neutrophils as compared to both control and thermal exposure values from 11�17 days of experiment. The data generated from this study help us to understand the functional relationship between pineal, adrenal, and immune system, and how this relationship modifies the non-specific immune response for the well being of goats during thermal stress.
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