Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients

• Autores: Xu Liang, Jie Zhang, Yulin Zhu, Yuanli Lu, Xinna Zhou, Zheng Wang, Jing Yu, Ying Yan, Lijun Di, Li Che, Hanfang Jiang, Huabing Yang, Herbert Kim Lyerly, Jun Ren
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 15, Nº. 4, 2013, págs. 331-334
• Idioma: inglés
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• Resumen

  • Aim This study was designed to explore the genetic polymorphism of IL-10 (-1082A/G, -592A/C, -819T/C), TNF-? (-308G/A) with susceptibility to docetaxel-induced liver injury (DILI) in Chinese breast cancer patients.

    Methods The targeted genetic polymorphisms of IL10-1082G/A, IL10-592A/C, IL10-819T/C, TNF-308G/A from 40 patients with DILI were assayed by matrix-assisted laser desorption/ionization-time of flight of Sequenom.

    Results AA genotype of IL10-592 and TT of IL10-819 significantly increased incidence of DILI (P = 0.005, OR = 3.137). No differences of TNF gene polymorphism between the two groups were seen.

    Conclusion The genetic polymorphism of the IL10-592A/C AA genotype and IL10-819T/C TT genotype was predominantly conferred to the incidence of docetaxel-induced liver injury.