Pancreas Transplantation and Reversal of Diabetic Nephropathy Lesions

• Autores: Michael Mauer, Paola Fioretto
• Localización: Medical clinics of North America, ISSN 0025-7125, Vol. 97, Nº. 1, 2013 (Ejemplar dedicado a: Diabetic chronic kidney disease), págs. 109-114
• Idioma: inglés
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• Resumen

  • Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.