The Genetic Risk of Kidney Disease in Type 2 Diabetes

• Autores: Marcus G. Pezzolesi, Andrzej S. Krolewski
• Localización: Medical clinics of North America, ISSN 0025-7125, Vol. 97, Nº. 1, 2013 (Ejemplar dedicado a: Diabetic chronic kidney disease), págs. 91-107
• Idioma: inglés
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• Resumen

  • In this review, the authors discuss the major approaches being used to identify diabetic nephropathy (DN) susceptibility genes in type 2 diabetes (T2D) and highlight the salient findings from studies whereby these approaches have been implemented. The recent advent of next-generation sequencing technology is beginning to impact DN gene mapping strategies. As the field moves forward, family based approaches should greatly facilitate efforts to identify variants in genes that have a major effect on the risk of DN in T2D. To be successful, the ascertainment and comprehensive study of families with multiple affected members is critical.