Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion

• Autores: K. N. Nilaweera, L. Giblin, R. B. Ross
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 66, Nº. 1, 2010, págs. 85-92
• Idioma: inglés
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• Resumen

  • The hormone cholecystokinin is produced by the enteroendocrine I cells in the intestine, and it plays an important role in a number of physiological processes including digestion and food intake. Recent data suggest that cholecystokinin gene expression and protein secretion are regulated by macronutrients. The mechanism involves a change in intracellular levels of cAMP and Ca+2, brought about by the activity of a number of nutrient-responsive G protein-coupled receptors, nutrient transporters, ion channels and intracellular enzymes. How these intracellular responses could lead to gene expression and protein secretion are discussed along with new directions for future investigation.