Advances in Blood Group Genotyping

• Autores: María Rios
• Localización: Gaceta médica de México, ISSN 0016-3813, Vol. 136, Nº. Extra 2, 2000, págs. 79-83
• Idioma: inglés
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• Resumen

  • The success of a blood transfusion event relies accurate blood typing. The importance of blood typing importance increases with the number of transfusions and consequent alloimmunization. Hemagglutination has been the assay of choice for blood typing because it is simple and does not require sophisticated technical skills or equipment. However, its interpretation is subjective because it depends on the quality of anti-sera. Extended red cell typing of transfusion dependent patients who have developed allo or autoantibodies remains a difficult laboratory problem.

    Transfusion dependent patients are defined as those who require frequent transfusion throughout their lives. Among them are patients with aplastic anemia, some with myelodysplasia who are not eligible for stem cell transplantation, thalassemia, selected patients with sickle cell anemia who are managed with transfusion therapy, and patients with autoimmune hemolytic. Cell typing of sensitized patients is essential confirm the identity of suspected alloantibodies, and to facilitate the identification of antibodies that may develop in the future. In some occasions, typing of a heavily transfused patients is difficult because it is difficult to distinguish between donor and patient cells.